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These potential cardioprotective effects may be related to the favourable actions of metformin on lipid metabolism, vascular smooth muscle, hypercoagulation, platelet hyperactivity, cardiomyocyte intracellular calcium handling and endothelial function [24]

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In women with PCOS, hyperandrogenism, insulin resistance, and adipose-derived inflammatory cues have been associated with altered neutrophil activation profiles, including increased oxidative stress, degranulation, and markers suggestive of neutrophil extracellular trap (NET) formation